Probing the Gold Binding Site in Serum Albumin
نویسندگان
چکیده
The antiarthritic drug, aumnofin ("Ridaura’) is an orally-active antiarthdtic drug containing linear Au(I). The gold is co-ordinated by triethylphosphine and the sulfur of tetraacetyl-I-D-1thioglucose (HSATg). Deacetylation occurs during absorption and then the thioglucose is displaced via ligand displacement reactions. Over 80% of the gold in the blood is carded by serum albumin, a 66 kDa single-chain protein with high helical content and three strucumlly similar domains.2
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ورودعنوان ژورنال:
- Metal-Based Drugs
دوره 1 شماره
صفحات -
تاریخ انتشار 1994